Drug interactions
Darolutamide + Methotrexate
Severity: Moderate
Darolutamide and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP and may increase exposure to methotrexate, a BCRP substrate. This could increase methotrexate toxicity such as myelosuppression and mucositis.
What this interaction means in plain words
Darolutamide and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Methotrexate belongs to Oncology.
Why it happens
Inhibition of BCRP-mediated efflux increases methotrexate absorption and reduces its elimination.
What to do
Monitor blood counts, renal function and signs of methotrexate toxicity, and consider reducing the methotrexate dose. Use extra caution with high-dose regimens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Methotrexate?
MediHelp rates the interaction as moderate. Darolutamide and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP and may increase exposure to methotrexate, a BCRP substrate. This could increase methotrexate toxicity such as myelosuppression and mucositis.
How serious is the interaction between Darolutamide and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, renal function and signs of methotrexate toxicity, and consider reducing the methotrexate dose. Use extra caution with high-dose regimens.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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