Drug interactions
Darolutamide + Pitavastatin
Severity: Moderate
Darolutamide and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits the efflux transporter BCRP, which can raise systemic exposure to pitavastatin. Higher statin levels increase the likelihood of muscle toxicity such as myopathy.
What this interaction means in plain words
Darolutamide and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Pitavastatin belongs to Cardiovascular.
Why it happens
Inhibition of BCRP by darolutamide reduces efflux and increases pitavastatin exposure.
What to do
Monitor for muscle pain, weakness and CK elevation, and consider using the lowest effective pitavastatin dose. Switch to a statin that is not a BCRP substrate if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Pitavastatin?
MediHelp rates the interaction as moderate. Darolutamide and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits the efflux transporter BCRP, which can raise systemic exposure to pitavastatin. Higher statin levels increase the likelihood of muscle toxicity such as myopathy.
How serious is the interaction between Darolutamide and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and CK elevation, and consider using the lowest effective pitavastatin dose. Switch to a statin that is not a BCRP substrate if symptoms develop.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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