Drug interactions
Darolutamide + Tenofovir disoproxil
Severity: Minor
Darolutamide and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP and may modestly raise concentrations of BCRP substrates. Tenofovir is primarily renally eliminated, so a clinically significant effect is uncertain.
What this interaction means in plain words
Darolutamide and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of BCRP efflux transport by darolutamide may increase tenofovir exposure.
What to do
Monitor renal function and tenofovir-related adverse effects; no empiric dose change is generally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Darolutamide and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darolutamide inhibits BCRP and may modestly raise concentrations of BCRP substrates. Tenofovir is primarily renally eliminated, so a clinically significant effect is uncertain.
How serious is the interaction between Darolutamide and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and tenofovir-related adverse effects; no empiric dose change is generally needed.
What other medicines interact with Darolutamide?
MediHelp also lists interactions of Darolutamide with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Darolutamide page.
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