Drug interactions
Dasatinib + Saquinavir
Severity: Contraindicated
Dasatinib and Saquinavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir strongly inhibits CYP3A4 and can markedly raise dasatinib levels, and both drugs prolong the QT interval. This markedly increases the risk of torsades de pointes and dasatinib toxicity.
What this interaction means in plain words
Dasatinib and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
CYP3A4 inhibition increases dasatinib exposure, with additive QT prolongation.
What to do
Avoid the combination and choose an antiretroviral without strong CYP3A4 inhibition or QT effects.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dasatinib
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
- Amobarbital + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Saquinavir?
MediHelp rates the interaction as contraindicated. Dasatinib and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Saquinavir strongly inhibits CYP3A4 and can markedly raise dasatinib levels, and both drugs prolong the QT interval. This markedly increases the risk of torsades de pointes and dasatinib toxicity.
How serious is the interaction between Dasatinib and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antiretroviral without strong CYP3A4 inhibition or QT effects.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Dasatinib page.
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