Drug interactions
Dasatinib + Thioridazine
Severity: Contraindicated
Dasatinib and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine has a marked QT-prolonging effect and dasatinib can also prolong the QT interval. Together they substantially raise the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Dasatinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dasatinib belongs to Oncology; Thioridazine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization through potassium channel effects.
What to do
Avoid the combination and choose an antipsychotic with lower QT risk. If dasatinib is essential, do not use thioridazine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
- Amobarbital + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Thioridazine?
MediHelp rates the interaction as contraindicated. Dasatinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine has a marked QT-prolonging effect and dasatinib can also prolong the QT interval. Together they substantially raise the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Dasatinib and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic with lower QT risk. If dasatinib is essential, do not use thioridazine.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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