Drug interactions
Amitriptyline + Dasatinib
Severity: Major
Amitriptyline and Dasatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib prolongs the QT interval and amitriptyline does as well, so the combination adds arrhythmic risk. Dasatinib is a weak CYP3A4 inhibitor, and any effect on amitriptyline levels is probably small.
What this interaction means in plain words
Amitriptyline and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Dasatinib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible minor CYP3A4 inhibition by dasatinib.
What to do
Avoid if possible; otherwise obtain a baseline ECG, correct hypokalaemia and hypomagnesaemia, and monitor the QTc periodically. Reduce the amitriptyline dose if anticholinergic or cardiac toxicity appears.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amobarbital + Dasatinib Major
Frequently asked questions
Can I take Amitriptyline with Dasatinib?
MediHelp rates the interaction as major. Amitriptyline and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib prolongs the QT interval and amitriptyline does as well, so the combination adds arrhythmic risk. Dasatinib is a weak CYP3A4 inhibitor, and any effect on amitriptyline levels is probably small.
How serious is the interaction between Amitriptyline and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain a baseline ECG, correct hypokalaemia and hypomagnesaemia, and monitor the QTc periodically. Reduce the amitriptyline dose if anticholinergic or cardiac toxicity appears.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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