Drug interactions
Daunorubicin + Erythromycin ethylsuccinate
Severity: Moderate
Daunorubicin and Erythromycin ethylsuccinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits P-glycoprotein and may increase daunorubicin exposure. This could intensify myelosuppression, mucositis and cardiotoxicity, though documented clinical data are limited.
What this interaction means in plain words
Daunorubicin and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits P-glycoprotein-mediated efflux of daunorubicin.
What to do
Monitor blood counts and signs of toxicity; consider an alternative antibiotic such as a non-macrolide where practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Frequently asked questions
Can I take Daunorubicin with Erythromycin ethylsuccinate?
MediHelp rates the interaction as moderate. Daunorubicin and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits P-glycoprotein and may increase daunorubicin exposure. This could intensify myelosuppression, mucositis and cardiotoxicity, though documented clinical data are limited.
How serious is the interaction between Daunorubicin and Erythromycin ethylsuccinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of toxicity; consider an alternative antibiotic such as a non-macrolide where practical.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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