Drug interactions
Daunorubicin + Ifosfamide
Severity: Moderate
Daunorubicin and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daunorubicin is cardiotoxic and ifosfamide can also cause cardiac toxicity, so the combination may raise the risk of cardiomyopathy or arrhythmia. Myelosuppression is also additive.
What this interaction means in plain words
Daunorubicin and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Ifosfamide belongs to Oncology.
Why it happens
Additive cardiotoxicity and myelosuppression.
What to do
Assess cardiac function before and during treatment and track cumulative anthracycline dose. Monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Frequently asked questions
Can I take Daunorubicin with Ifosfamide?
MediHelp rates the interaction as moderate. Daunorubicin and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daunorubicin is cardiotoxic and ifosfamide can also cause cardiac toxicity, so the combination may raise the risk of cardiomyopathy or arrhythmia. Myelosuppression is also additive.
How serious is the interaction between Daunorubicin and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess cardiac function before and during treatment and track cumulative anthracycline dose. Monitor blood counts.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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