Drug interactions
Daunorubicin + Nefazodone
Severity: Moderate
Daunorubicin and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits P-glycoprotein and CYP3A4 and may increase daunorubicin exposure. This could increase myelosuppression and cardiotoxicity; nefazodone also carries hepatotoxicity risk.
What this interaction means in plain words
Daunorubicin and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits P-gp efflux of daunorubicin.
What to do
Consider an alternative antidepressant; if combined, monitor blood counts, liver tests and cardiac function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Frequently asked questions
Can I take Daunorubicin with Nefazodone?
MediHelp rates the interaction as moderate. Daunorubicin and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone inhibits P-glycoprotein and CYP3A4 and may increase daunorubicin exposure. This could increase myelosuppression and cardiotoxicity; nefazodone also carries hepatotoxicity risk.
How serious is the interaction between Daunorubicin and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antidepressant; if combined, monitor blood counts, liver tests and cardiac function.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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