Drug interactions
Daunorubicin + Nilotinib
Severity: Moderate
Daunorubicin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and may increase daunorubicin exposure, potentially worsening myelosuppression and cardiotoxicity. Both drugs can also affect cardiac conduction or function, adding to concern.
What this interaction means in plain words
Daunorubicin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux of daunorubicin by nilotinib, plus additive cardiac effects including QT prolongation.
What to do
Monitor blood counts, ECG with QTc, and cardiac function. Correct potassium and magnesium and reduce daunorubicin dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Daunorubicin with Nilotinib?
MediHelp rates the interaction as moderate. Daunorubicin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits P-glycoprotein and may increase daunorubicin exposure, potentially worsening myelosuppression and cardiotoxicity. Both drugs can also affect cardiac conduction or function, adding to concern.
How serious is the interaction between Daunorubicin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, ECG with QTc, and cardiac function. Correct potassium and magnesium and reduce daunorubicin dose if toxicity occurs.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporin. The full list is on the Daunorubicin page.
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