Drug interactions
Daunorubicin + Palifermin
Severity: Moderate
Daunorubicin and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth, and if given close to cytotoxic chemotherapy it can make rapidly dividing mucosal cells more sensitive, worsening oral mucositis. Labeling advises a gap around chemotherapy administration.
What this interaction means in plain words
Daunorubicin and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-induced epithelial proliferation increases sensitivity of mucosal cells to cytotoxic damage.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after daunorubicin. Follow the labeled schedule for the mucositis-prevention regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Daunorubicin and Palifermin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Other interactions of Palifermin
Frequently asked questions
Can I take Daunorubicin with Palifermin?
MediHelp rates the interaction as moderate. Daunorubicin and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin stimulates epithelial cell growth, and if given close to cytotoxic chemotherapy it can make rapidly dividing mucosal cells more sensitive, worsening oral mucositis. Labeling advises a gap around chemotherapy administration.
How serious is the interaction between Daunorubicin and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after daunorubicin. Follow the labeled schedule for the mucositis-prevention regimen.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporin. The full list is on the Daunorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
