Drug interactions
Daunorubicin + Safinamide
Severity: Minor
Daunorubicin and Safinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide and its main metabolite can inhibit intestinal BCRP. Daunorubicin is not a well-established clinically relevant BCRP substrate when given intravenously, so the effect is likely to be small. The interaction is largely theoretical.
What this interaction means in plain words
Daunorubicin and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daunorubicin belongs to Oncology; Safinamide belongs to Central Nervous System.
Why it happens
Inhibition of intestinal BCRP by safinamide may theoretically raise exposure to BCRP substrates.
What to do
No routine change is needed. Monitor for increased anthracycline toxicity such as myelosuppression if clinically suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Frequently asked questions
Can I take Daunorubicin with Safinamide?
MediHelp rates the interaction as minor. Daunorubicin and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide and its main metabolite can inhibit intestinal BCRP. Daunorubicin is not a well-established clinically relevant BCRP substrate when given intravenously, so the effect is likely to be small. The interaction is largely theoretical.
How serious is the interaction between Daunorubicin and Safinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for increased anthracycline toxicity such as myelosuppression if clinically suspected.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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