Drug interactions
Debrisoquine + Desipramine
Severity: Moderate
Debrisoquine and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine blocks uptake of debrisoquine into adrenergic neurons, which reduces its antihypertensive effect. Blood pressure control may be lost when a tricyclic is started.
What this interaction means in plain words
Debrisoquine and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of neuronal amine uptake pump needed for debrisoquine's action.
What to do
Monitor blood pressure when starting or stopping desipramine and adjust the antihypertensive regimen. Consider a different antihypertensive class.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Debrisoquine with Desipramine?
MediHelp rates the interaction as moderate. Debrisoquine and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine blocks uptake of debrisoquine into adrenergic neurons, which reduces its antihypertensive effect. Blood pressure control may be lost when a tricyclic is started.
How serious is the interaction between Debrisoquine and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping desipramine and adjust the antihypertensive regimen. Consider a different antihypertensive class.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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