Drug interactions
Deferasirox + Diclofenac
Severity: Major
Deferasirox and Diclofenac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can itself cause gastrointestinal irritation, ulceration and hemorrhage, and diclofenac has similar effects. Combined use increases the risk of serious GI bleeding, and both agents can also affect renal function.
What this interaction means in plain words
Deferasirox and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Diclofenac belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity and nephrotoxic potential from both drugs.
What to do
Avoid the combination where possible, or use gastroprotection and monitor for GI bleeding. Monitor serum creatinine and watch for signs of anemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Diclofenac?
MediHelp rates the interaction as major. Deferasirox and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox can itself cause gastrointestinal irritation, ulceration and hemorrhage, and diclofenac has similar effects. Combined use increases the risk of serious GI bleeding, and both agents can also affect renal function.
How serious is the interaction between Deferasirox and Diclofenac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use gastroprotection and monitor for GI bleeding. Monitor serum creatinine and watch for signs of anemia.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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