Drug interactions
Deferasirox + Diflunisal
Severity: Major
Deferasirox and Diflunisal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause gastrointestinal irritation, ulceration and bleeding, and both can affect renal function. Using them together raises the risk of serious GI hemorrhage and kidney injury.
What this interaction means in plain words
Deferasirox and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Diflunisal belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity and renal effects; NSAIDs also impair platelet function.
What to do
Avoid the combination where an alternative analgesic exists. If unavoidable, monitor renal function, blood counts and for GI bleeding, with gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Diflunisal?
MediHelp rates the interaction as major. Deferasirox and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause gastrointestinal irritation, ulceration and bleeding, and both can affect renal function. Using them together raises the risk of serious GI hemorrhage and kidney injury.
How serious is the interaction between Deferasirox and Diflunisal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative analgesic exists. If unavoidable, monitor renal function, blood counts and for GI bleeding, with gastroprotection.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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