Drug interactions
Deferasirox + Etodolac
Severity: Major
Deferasirox and Etodolac: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can irritate the gastrointestinal tract and cause ulceration and bleeding, and both may harm the kidneys. Using them together increases the risk of serious GI hemorrhage and renal toxicity.
What this interaction means in plain words
Deferasirox and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Etodolac belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity and nephrotoxic effects.
What to do
Avoid the combination if possible; otherwise monitor renal function and for GI bleeding, and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Etodolac?
MediHelp rates the interaction as major. Deferasirox and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can irritate the gastrointestinal tract and cause ulceration and bleeding, and both may harm the kidneys. Using them together increases the risk of serious GI hemorrhage and renal toxicity.
How serious is the interaction between Deferasirox and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor renal function and for GI bleeding, and consider gastroprotection.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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