Drug interactions
Deferasirox + Felodipine
Severity: Minor
Deferasirox and Felodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may induce CYP3A4 and lower felodipine exposure, which could reduce blood pressure control. The effect is variable and has been described mainly from pharmacokinetic data with other CYP3A4 substrates.
What this interaction means in plain words
Deferasirox and Felodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deferasirox belongs to Miscellaneous; Felodipine belongs to Cardiovascular.
Why it happens
Possible CYP3A4 induction by deferasirox accelerates felodipine metabolism.
What to do
Monitor blood pressure when deferasirox is started or stopped and increase the felodipine dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Felodipine?
MediHelp rates the interaction as minor. Deferasirox and Felodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferasirox may induce CYP3A4 and lower felodipine exposure, which could reduce blood pressure control. The effect is variable and has been described mainly from pharmacokinetic data with other CYP3A4 substrates.
How serious is the interaction between Deferasirox and Felodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when deferasirox is started or stopped and increase the felodipine dose if control is lost.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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