Drug interactions
Deferasirox + Imatinib
Severity: Moderate
Deferasirox and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can alter CYP3A4 activity and may lower imatinib concentrations, possibly reducing efficacy. Deferasirox itself also causes renal and hepatic toxicity.
What this interaction means in plain words
Deferasirox and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Imatinib belongs to Oncology.
Why it happens
Deferasirox may induce CYP3A4 and increase imatinib clearance.
What to do
Monitor treatment response, including molecular markers in CML, and imatinib trough levels if available. Increase imatinib dose only if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Imatinib?
MediHelp rates the interaction as moderate. Deferasirox and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can alter CYP3A4 activity and may lower imatinib concentrations, possibly reducing efficacy. Deferasirox itself also causes renal and hepatic toxicity.
How serious is the interaction between Deferasirox and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response, including molecular markers in CML, and imatinib trough levels if available. Increase imatinib dose only if response is inadequate.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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