Drug interactions
Deferasirox + Indomethacin
Severity: Major
Deferasirox and Indomethacin: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause gastrointestinal irritation, ulceration and hemorrhage, and both can impair renal function. Using them together increases the risk of serious GI bleeding and kidney injury.
What this interaction means in plain words
Deferasirox and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Indomethacin belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity and nephrotoxicity, with NSAID-related platelet inhibition adding to bleeding risk.
What to do
Avoid the combination where possible, choosing a non-NSAID analgesic. If unavoidable, use gastroprotection and monitor renal function and signs of GI bleeding closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Indomethacin?
MediHelp rates the interaction as major. Deferasirox and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause gastrointestinal irritation, ulceration and hemorrhage, and both can impair renal function. Using them together increases the risk of serious GI bleeding and kidney injury.
How serious is the interaction between Deferasirox and Indomethacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, choosing a non-NSAID analgesic. If unavoidable, use gastroprotection and monitor renal function and signs of GI bleeding closely.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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