Drug interactions
Deferasirox + Ketoprofen
Severity: Major
Deferasirox and Ketoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause gastrointestinal irritation, ulceration and hemorrhage, and both can adversely affect renal function. Combined use raises the risk of serious GI bleeding and kidney injury.
What this interaction means in plain words
Deferasirox and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity and nephrotoxicity, with NSAID-related reduction in renal prostaglandins.
What to do
Avoid the combination where possible; if needed, monitor serum creatinine and for GI bleeding, and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Ketoprofen?
MediHelp rates the interaction as major. Deferasirox and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause gastrointestinal irritation, ulceration and hemorrhage, and both can adversely affect renal function. Combined use raises the risk of serious GI bleeding and kidney injury.
How serious is the interaction between Deferasirox and Ketoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, monitor serum creatinine and for GI bleeding, and consider gastroprotection.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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