Drug interactions
Deferasirox + Lapatinib
Severity: Moderate
Deferasirox and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may lower lapatinib concentrations through CYP3A4 induction, though the effect is variable. Reduced lapatinib exposure may decrease efficacy.
What this interaction means in plain words
Deferasirox and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Lapatinib belongs to Oncology.
Why it happens
Deferasirox may induce CYP3A4 metabolism of lapatinib.
What to do
Monitor tumor response and consider an alternative iron chelator if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Lapatinib?
MediHelp rates the interaction as moderate. Deferasirox and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may lower lapatinib concentrations through CYP3A4 induction, though the effect is variable. Reduced lapatinib exposure may decrease efficacy.
How serious is the interaction between Deferasirox and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider an alternative iron chelator if efficacy appears reduced.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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