Drug interactions
Deferasirox + Mexiletine
Severity: Moderate
Deferasirox and Mexiletine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox inhibits CYP1A2 and may raise mexiletine concentrations. Because mexiletine has a narrow therapeutic window, toxicity such as tremor, dizziness and GI upset may occur.
What this interaction means in plain words
Deferasirox and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Mexiletine belongs to Cardiovascular.
Why it happens
Deferasirox inhibits CYP1A2 metabolism of mexiletine.
What to do
Monitor for mexiletine toxicity and consider a dose reduction; check ECG if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Mexiletine?
MediHelp rates the interaction as moderate. Deferasirox and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP1A2 and may raise mexiletine concentrations. Because mexiletine has a narrow therapeutic window, toxicity such as tremor, dizziness and GI upset may occur.
How serious is the interaction between Deferasirox and Mexiletine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mexiletine toxicity and consider a dose reduction; check ECG if symptoms appear.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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