Drug interactions
Deferasirox + Nicardipine
Severity: Moderate
Deferasirox and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox has variable effects on CYP3A4 and may lower nicardipine concentrations, reducing blood pressure control. The effect is likely modest but may be noticeable in some patients.
What this interaction means in plain words
Deferasirox and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Nicardipine belongs to Cardiovascular.
Why it happens
Deferasirox induces CYP3A4-mediated metabolism of nicardipine, reducing its exposure.
What to do
Monitor blood pressure after starting or stopping deferasirox. Titrate nicardipine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Nicardipine?
MediHelp rates the interaction as moderate. Deferasirox and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox has variable effects on CYP3A4 and may lower nicardipine concentrations, reducing blood pressure control. The effect is likely modest but may be noticeable in some patients.
How serious is the interaction between Deferasirox and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping deferasirox. Titrate nicardipine dose as needed.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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