Drug interactions
Deferasirox + Oxaprozin
Severity: Major
Deferasirox and Oxaprozin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the gastrointestinal mucosa and cause bleeding, and deferasirox also carries renal toxicity. Together they raise the risk of ulceration, hemorrhage and renal impairment.
What this interaction means in plain words
Deferasirox and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity, with NSAID antiplatelet effects and potential additive nephrotoxicity.
What to do
Avoid combination if possible; otherwise use gastroprotection and monitor for GI bleeding, serum creatinine and blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Oxaprozin?
MediHelp rates the interaction as major. Deferasirox and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the gastrointestinal mucosa and cause bleeding, and deferasirox also carries renal toxicity. Together they raise the risk of ulceration, hemorrhage and renal impairment.
How serious is the interaction between Deferasirox and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination if possible; otherwise use gastroprotection and monitor for GI bleeding, serum creatinine and blood counts.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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