Drug interactions
Deferasirox + Paclitaxel
Severity: Moderate
Deferasirox and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox inhibits CYP2C8, a main route of paclitaxel metabolism, and can raise paclitaxel exposure. This may increase myelosuppression and neuropathy.
What this interaction means in plain words
Deferasirox and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Paclitaxel belongs to Oncology.
Why it happens
CYP2C8 inhibition by deferasirox reduces paclitaxel metabolism.
What to do
Monitor blood counts and neurotoxicity and lower the paclitaxel dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Paclitaxel?
MediHelp rates the interaction as moderate. Deferasirox and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP2C8, a main route of paclitaxel metabolism, and can raise paclitaxel exposure. This may increase myelosuppression and neuropathy.
How serious is the interaction between Deferasirox and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity and lower the paclitaxel dose if adverse effects emerge.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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