Drug interactions
Deferasirox + Propafenone
Severity: Moderate
Deferasirox and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 modestly and may lower propafenone concentrations, though propafenone is cleared mainly by CYP2D6 with CYP3A4 and CYP1A2 as secondary routes. Reduced antiarrhythmic effect is possible. Deferasirox also inhibits CYP2D6 weakly, which could have the opposite effect.
What this interaction means in plain words
Deferasirox and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Propafenone belongs to Cardiovascular.
Why it happens
Deferasirox alters CYP enzyme activity (CYP3A4 induction, CYP2D6 and CYP1A2 inhibition), changing propafenone exposure unpredictably.
What to do
Monitor heart rhythm and clinical response to propafenone when starting or stopping deferasirox. Check ECG and adjust dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Propafenone?
MediHelp rates the interaction as moderate. Deferasirox and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 modestly and may lower propafenone concentrations, though propafenone is cleared mainly by CYP2D6 with CYP3A4 and CYP1A2 as secondary routes. Reduced antiarrhythmic effect is possible. Deferasirox also inhibits CYP2D6 weakly, which could have the opposite effect.
How serious is the interaction between Deferasirox and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm and clinical response to propafenone when starting or stopping deferasirox. Check ECG and adjust dose as needed.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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