Drug interactions
Deferasirox + Ramelteon
Severity: Moderate
Deferasirox and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox inhibits CYP1A2, the main enzyme metabolizing ramelteon, and may substantially raise ramelteon concentrations. This could increase drowsiness, dizziness and next-day impairment.
What this interaction means in plain words
Deferasirox and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Ramelteon belongs to Central Nervous System.
Why it happens
Deferasirox inhibits CYP1A2-mediated metabolism of ramelteon.
What to do
Monitor for excessive sedation and consider an alternative hypnotic not dependent on CYP1A2. Avoid driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Ramelteon?
MediHelp rates the interaction as moderate. Deferasirox and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP1A2, the main enzyme metabolizing ramelteon, and may substantially raise ramelteon concentrations. This could increase drowsiness, dizziness and next-day impairment.
How serious is the interaction between Deferasirox and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider an alternative hypnotic not dependent on CYP1A2. Avoid driving if drowsy.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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