Drug interactions
Deferasirox + Vancomycin
Severity: Moderate
Deferasirox and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can cause renal toxicity, including acute kidney injury and tubulopathy, and vancomycin is also nephrotoxic. Using them together may raise the risk of renal impairment beyond that of either drug alone.
What this interaction means in plain words
Deferasirox and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Vancomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity affecting the renal tubules.
What to do
Monitor serum creatinine and estimated clearance before and regularly during co-therapy, and check vancomycin trough or AUC levels. Reduce or interrupt deferasirox if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Vancomycin?
MediHelp rates the interaction as moderate. Deferasirox and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can cause renal toxicity, including acute kidney injury and tubulopathy, and vancomycin is also nephrotoxic. Using them together may raise the risk of renal impairment beyond that of either drug alone.
How serious is the interaction between Deferasirox and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and estimated clearance before and regularly during co-therapy, and check vancomycin trough or AUC levels. Reduce or interrupt deferasirox if renal function declines.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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