Drug interactions
Deferiprone + Nelarabine
Severity: Major
Deferiprone and Nelarabine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelarabine causes myelosuppression including neutropenia, in addition to its neurotoxicity. With deferiprone, severe neutropenia may be more likely.
What this interaction means in plain words
Deferiprone and Nelarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Nelarabine belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Avoid the combination if possible; otherwise monitor absolute neutrophil count frequently and withhold deferiprone if neutropenia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Nelarabine
- Nelarabine + Pentostatin Major
- Nelarabine + Siponimod Major
- Nelarabine + Tofacitinib Major
- Denosumab + Nelarabine Moderate
- Fingolimod + Nelarabine Moderate
- Hydroxyurea + Nelarabine Moderate
Frequently asked questions
Can I take Deferiprone with Nelarabine?
MediHelp rates the interaction as major. Deferiprone and Nelarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nelarabine causes myelosuppression including neutropenia, in addition to its neurotoxicity. With deferiprone, severe neutropenia may be more likely.
How serious is the interaction between Deferiprone and Nelarabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor absolute neutrophil count frequently and withhold deferiprone if neutropenia occurs.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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