Drug interactions
Fingolimod + Nelarabine
Severity: Moderate
Fingolimod and Nelarabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelarabine is a cytotoxic purine analogue causing myelosuppression and neurotoxicity. With fingolimod's lymphocyte-lowering effect, the risk of infection may increase.
What this interaction means in plain words
Fingolimod and Nelarabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Nelarabine belongs to Oncology.
Why it happens
Additive pharmacodynamic immunosuppression from cytotoxic myelosuppression and lymphocyte sequestration.
What to do
Monitor blood counts and infection signs. Consider interrupting fingolimod during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Nelarabine
- Deferiprone + Nelarabine Major
- Nelarabine + Pentostatin Major
- Nelarabine + Siponimod Major
- Nelarabine + Tofacitinib Major
- Denosumab + Nelarabine Moderate
- Hydroxyurea + Nelarabine Moderate
Frequently asked questions
Can I take Fingolimod with Nelarabine?
MediHelp rates the interaction as moderate. Fingolimod and Nelarabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelarabine is a cytotoxic purine analogue causing myelosuppression and neurotoxicity. With fingolimod's lymphocyte-lowering effect, the risk of infection may increase.
How serious is the interaction between Fingolimod and Nelarabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and infection signs. Consider interrupting fingolimod during chemotherapy.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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