Drug interactions
Deferiprone + Pazopanib
Severity: Major
Deferiprone and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone can cause neutropenia and agranulocytosis, and pazopanib can also cause myelosuppression, including neutropenia. Using both together may raise the risk of serious infection from low neutrophil counts.
What this interaction means in plain words
Deferiprone and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Pazopanib belongs to Oncology.
Why it happens
Additive hematologic toxicity (pharmacodynamic) with overlapping neutropenic effects.
What to do
Avoid the combination if an alternative exists; otherwise monitor absolute neutrophil count more often than the usual weekly schedule for deferiprone. Interrupt deferiprone if neutropenia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Deferiprone with Pazopanib?
MediHelp rates the interaction as major. Deferiprone and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause neutropenia and agranulocytosis, and pazopanib can also cause myelosuppression, including neutropenia. Using both together may raise the risk of serious infection from low neutrophil counts.
How serious is the interaction between Deferiprone and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists; otherwise monitor absolute neutrophil count more often than the usual weekly schedule for deferiprone. Interrupt deferiprone if neutropenia develops.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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