Drug interactions
Deflazacort + Dobutamine
Severity: Moderate
Deflazacort and Dobutamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine and deflazacort can each lower serum potassium, so using them together may produce additive hypokalemia. This can increase the risk of arrhythmia, particularly in patients with heart failure or on other potassium-lowering drugs.
What this interaction means in plain words
Deflazacort and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Dobutamine belongs to Cardiovascular.
Why it happens
Beta-2 adrenergic stimulation shifts potassium into cells while corticosteroid mineralocorticoid activity promotes renal potassium loss, giving additive hypokalemia.
What to do
Monitor serum potassium and ECG during co-administration and replace potassium as needed. Take extra care in patients also receiving diuretics or digoxin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Dobutamine?
MediHelp rates the interaction as moderate. Deflazacort and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine and deflazacort can each lower serum potassium, so using them together may produce additive hypokalemia. This can increase the risk of arrhythmia, particularly in patients with heart failure or on other potassium-lowering drugs.
How serious is the interaction between Deflazacort and Dobutamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during co-administration and replace potassium as needed. Take extra care in patients also receiving diuretics or digoxin.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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