Drug interactions
Deflazacort + Flurbiprofen
Severity: Moderate
Deflazacort and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and NSAIDs each damage the gastroduodenal mucosa, and using them together raises the risk of peptic ulceration and GI bleeding. The risk is greatest in older patients and with prolonged or high-dose therapy.
What this interaction means in plain words
Deflazacort and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury: NSAID prostaglandin suppression combined with corticosteroid impairment of mucosal healing.
What to do
Add a proton pump inhibitor in patients needing both agents long term and use the lowest effective doses for the shortest time. Monitor for dyspepsia and signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Flurbiprofen?
MediHelp rates the interaction as moderate. Deflazacort and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and NSAIDs each damage the gastroduodenal mucosa, and using them together raises the risk of peptic ulceration and GI bleeding. The risk is greatest in older patients and with prolonged or high-dose therapy.
How serious is the interaction between Deflazacort and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a proton pump inhibitor in patients needing both agents long term and use the lowest effective doses for the shortest time. Monitor for dyspepsia and signs of GI bleeding.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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