Drug interactions
Deflazacort + Gliclazide
Severity: Moderate
Deflazacort and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a systemic glucocorticoid that can raise blood glucose and reduce the effect of gliclazide, particularly with prolonged use or higher doses.
What this interaction means in plain words
Deflazacort and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Gliclazide belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose production.
What to do
Monitor blood glucose during deflazacort therapy and increase gliclazide or other antidiabetic doses as needed, reducing them when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Gliclazide?
MediHelp rates the interaction as moderate. Deflazacort and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a systemic glucocorticoid that can raise blood glucose and reduce the effect of gliclazide, particularly with prolonged use or higher doses.
How serious is the interaction between Deflazacort and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during deflazacort therapy and increase gliclazide or other antidiabetic doses as needed, reducing them when the steroid is tapered.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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