Drug interactions
Deflazacort + Glipizide-metformin
Severity: Moderate
Deflazacort and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort, a systemic glucocorticoid, can raise blood glucose and reduce the effectiveness of glipizide and metformin. Hyperglycemia may appear or worsen during treatment, especially at higher doses or longer courses.
What this interaction means in plain words
Deflazacort and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Glipizide-metformin belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and induce peripheral insulin resistance, opposing the antidiabetic drugs.
What to do
Monitor blood glucose more frequently during steroid therapy and adjust the antidiabetic regimen as needed, then reduce doses again when the steroid is stopped to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Glipizide-metformin?
MediHelp rates the interaction as moderate. Deflazacort and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort, a systemic glucocorticoid, can raise blood glucose and reduce the effectiveness of glipizide and metformin. Hyperglycemia may appear or worsen during treatment, especially at higher doses or longer courses.
How serious is the interaction between Deflazacort and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently during steroid therapy and adjust the antidiabetic regimen as needed, then reduce doses again when the steroid is stopped to avoid hypoglycemia.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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