Drug interactions
Deflazacort + Ibuprofen
Severity: Moderate
Deflazacort and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids taken with NSAIDs increase the likelihood of peptic ulceration and gastrointestinal bleeding. Risk rises with higher doses and longer duration.
What this interaction means in plain words
Deflazacort and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Ibuprofen belongs to Musculoskeletal.
Why it happens
Additive impairment of gastric mucosal defense from NSAID prostaglandin inhibition and corticosteroid effects.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor. Monitor for dyspepsia, melena or other bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deflazacort and Ibuprofen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Ibuprofen?
MediHelp rates the interaction as moderate. Deflazacort and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids taken with NSAIDs increase the likelihood of peptic ulceration and gastrointestinal bleeding. Risk rises with higher doses and longer duration.
How serious is the interaction between Deflazacort and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor. Monitor for dyspepsia, melena or other bleeding signs.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
