Drug interactions
Deflazacort + Insulin degludec-liraglutide
Severity: Moderate
Deflazacort and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a systemic corticosteroid that can raise blood glucose and also lower serum potassium. Insulin shifts potassium into cells, so combined hypokalemia is possible, and hyperglycemia may reduce the effect of the antidiabetic therapy.
What this interaction means in plain words
Deflazacort and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and gluconeogenesis oppose antidiabetic action, while corticosteroid mineralocorticoid effects and insulin both lower serum potassium.
What to do
Monitor blood glucose and serum potassium during deflazacort therapy, and increase the insulin dose as needed; reduce it when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Deflazacort and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a systemic corticosteroid that can raise blood glucose and also lower serum potassium. Insulin shifts potassium into cells, so combined hypokalemia is possible, and hyperglycemia may reduce the effect of the antidiabetic therapy.
How serious is the interaction between Deflazacort and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium during deflazacort therapy, and increase the insulin dose as needed; reduce it when the steroid is tapered.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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