Drug interactions
Deflazacort + Insulin glargine-lixisenatide
Severity: Moderate
Deflazacort and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Insulin drives potassium into cells and deflazacort, a corticosteroid, can promote potassium loss, so low potassium is possible. Glucocorticoids also cause hyperglycemia, which may raise insulin requirements.
What this interaction means in plain words
Deflazacort and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Additive hypokalemia (insulin-driven cellular uptake, corticosteroid renal loss) and glucocorticoid-induced insulin resistance.
What to do
Monitor serum potassium and blood glucose during corticosteroid therapy and adjust the insulin dose and potassium replacement as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Deflazacort and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Insulin drives potassium into cells and deflazacort, a corticosteroid, can promote potassium loss, so low potassium is possible. Glucocorticoids also cause hyperglycemia, which may raise insulin requirements.
How serious is the interaction between Deflazacort and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood glucose during corticosteroid therapy and adjust the insulin dose and potassium replacement as needed.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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