Drug interactions
Deflazacort + Insulin glulisine
Severity: Moderate
Deflazacort and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort, a corticosteroid, raises blood glucose and can offset the effect of insulin, so insulin needs may increase. Both drugs can also lower serum potassium, which raises the risk of hypokalemia with prolonged or high-dose steroid therapy.
What this interaction means in plain words
Deflazacort and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Insulin glulisine belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and gluconeogenesis oppose insulin action, while insulin-driven intracellular potassium shift and steroid mineralocorticoid effects additively lower serum potassium.
What to do
Monitor blood glucose closely and increase insulin doses as needed during deflazacort therapy, reducing them again when the steroid is tapered. Check serum potassium periodically and replace it if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Insulin glulisine?
MediHelp rates the interaction as moderate. Deflazacort and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort, a corticosteroid, raises blood glucose and can offset the effect of insulin, so insulin needs may increase. Both drugs can also lower serum potassium, which raises the risk of hypokalemia with prolonged or high-dose steroid therapy.
How serious is the interaction between Deflazacort and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and increase insulin doses as needed during deflazacort therapy, reducing them again when the steroid is tapered. Check serum potassium periodically and replace it if low.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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