Drug interactions
Deflazacort + Insulin isophane protamine human
Severity: Moderate
Deflazacort and Insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid that raises blood glucose and can reduce the effectiveness of insulin, so higher insulin doses are often needed. Both drugs can also lower serum potassium, though the main clinical concern is hyperglycemia.
What this interaction means in plain words
Deflazacort and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Insulin isophane protamine human belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose output oppose insulin; both agents additionally promote potassium loss or intracellular shift.
What to do
Monitor blood glucose more often when starting, increasing or stopping deflazacort and adjust the insulin dose accordingly. Check serum potassium in patients on prolonged therapy or at risk of hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Insulin isophane protamine human?
MediHelp rates the interaction as moderate. Deflazacort and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a glucocorticoid that raises blood glucose and can reduce the effectiveness of insulin, so higher insulin doses are often needed. Both drugs can also lower serum potassium, though the main clinical concern is hyperglycemia.
How serious is the interaction between Deflazacort and Insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting, increasing or stopping deflazacort and adjust the insulin dose accordingly. Check serum potassium in patients on prolonged therapy or at risk of hypokalemia.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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