Drug interactions
Deflazacort + Istradefylline
Severity: Minor
Deflazacort and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the 40 mg daily dose istradefylline weakly inhibits CYP3A4 and may modestly increase deflazacort active metabolite exposure. The effect is likely small and not seen at 20 mg daily.
What this interaction means in plain words
Deflazacort and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent weak CYP3A4 inhibition by istradefylline reduces metabolism of the active deflazacort metabolite.
What to do
Monitor for increased corticosteroid effects if istradefylline 40 mg daily is used. Consider a deflazacort dose reduction only if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Deflazacort with Istradefylline?
MediHelp rates the interaction as minor. Deflazacort and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At the 40 mg daily dose istradefylline weakly inhibits CYP3A4 and may modestly increase deflazacort active metabolite exposure. The effect is likely small and not seen at 20 mg daily.
How serious is the interaction between Deflazacort and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased corticosteroid effects if istradefylline 40 mg daily is used. Consider a deflazacort dose reduction only if adverse effects emerge.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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