Drug interactions
Deflazacort + Lactulose
Severity: Moderate
Deflazacort and Lactulose: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lactulose-induced diarrhea can cause potassium loss, and deflazacort adds renal potassium wasting. With excessive lactulose dosing, hypokalemia can develop.
What this interaction means in plain words
Deflazacort and Lactulose can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Lactulose belongs to Gastrointestinal Tract.
Why it happens
Additive potassium depletion from diarrheal losses (lactulose) and corticosteroid-related renal potassium excretion.
What to do
Monitor serum potassium, especially with high-dose or prolonged lactulose, and replace potassium as needed. Adjust lactulose to avoid diarrhea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lactulose
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Lactulose?
MediHelp rates the interaction as moderate. Deflazacort and Lactulose can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lactulose-induced diarrhea can cause potassium loss, and deflazacort adds renal potassium wasting. With excessive lactulose dosing, hypokalemia can develop.
How serious is the interaction between Deflazacort and Lactulose?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially with high-dose or prolonged lactulose, and replace potassium as needed. Adjust lactulose to avoid diarrhea.
What other medicines interact with Lactulose?
MediHelp also lists interactions of Lactulose with, for example, Dichlorphenamide, Aluminum hydroxide, Calcium carbonate. The full list is on the Lactulose page.
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