Drug interactions
Deflazacort + Meclofenamic acid
Severity: Moderate
Deflazacort and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids combined with NSAIDs raise the risk of peptic ulceration and gastrointestinal bleeding. The risk grows with higher doses and longer duration.
What this interaction means in plain words
Deflazacort and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury from NSAID prostaglandin inhibition and corticosteroid effects on mucosal protection and healing.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor for at-risk patients. Advise patients to report black stools or vomiting blood.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Meclofenamic acid?
MediHelp rates the interaction as moderate. Deflazacort and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids combined with NSAIDs raise the risk of peptic ulceration and gastrointestinal bleeding. The risk grows with higher doses and longer duration.
How serious is the interaction between Deflazacort and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor for at-risk patients. Advise patients to report black stools or vomiting blood.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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