Drug interactions
Deflazacort + Metformin-pioglitazone
Severity: Moderate
Deflazacort and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a systemic glucocorticoid that can raise blood glucose through increased insulin resistance and hepatic glucose output. This may reduce the effectiveness of metformin and pioglitazone, particularly with long-term use.
What this interaction means in plain words
Deflazacort and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism by glucocorticoid-induced insulin resistance.
What to do
Monitor blood glucose during therapy and increase antidiabetic doses if needed, then reduce them as the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Deflazacort and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a systemic glucocorticoid that can raise blood glucose through increased insulin resistance and hepatic glucose output. This may reduce the effectiveness of metformin and pioglitazone, particularly with long-term use.
How serious is the interaction between Deflazacort and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during therapy and increase antidiabetic doses if needed, then reduce them as the steroid is tapered.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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