Drug interactions
Deflazacort + Nateglinide
Severity: Moderate
Deflazacort and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid that raises blood glucose and can reduce the effectiveness of nateglinide. Glycemic control may worsen, especially during prolonged or higher-dose steroid courses.
What this interaction means in plain words
Deflazacort and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Nateglinide belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and hepatic gluconeogenesis oppose the glucose-lowering action.
What to do
Monitor blood glucose during deflazacort therapy and after stopping it. Increase the antidiabetic dose as needed and reduce it again when steroids are withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Nateglinide?
MediHelp rates the interaction as moderate. Deflazacort and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a glucocorticoid that raises blood glucose and can reduce the effectiveness of nateglinide. Glycemic control may worsen, especially during prolonged or higher-dose steroid courses.
How serious is the interaction between Deflazacort and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during deflazacort therapy and after stopping it. Increase the antidiabetic dose as needed and reduce it again when steroids are withdrawn.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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