Drug interactions
Deflazacort + Netupitant-palonosetron
Severity: Moderate
Deflazacort and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant inhibits CYP3A4, which converts deflazacort's active metabolite to inactive forms, so exposure to the active metabolite rises. This can increase corticosteroid adverse effects such as Cushingoid features, infection risk and hyperglycemia.
What this interaction means in plain words
Deflazacort and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 inhibition by netupitant reducing clearance of deflazacort's active metabolite.
What to do
Reduce the deflazacort dose to one-third of the usual dose during co-administration with moderate CYP3A4 inhibitors, per labeling. Monitor for corticosteroid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Deflazacort and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant inhibits CYP3A4, which converts deflazacort's active metabolite to inactive forms, so exposure to the active metabolite rises. This can increase corticosteroid adverse effects such as Cushingoid features, infection risk and hyperglycemia.
How serious is the interaction between Deflazacort and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the deflazacort dose to one-third of the usual dose during co-administration with moderate CYP3A4 inhibitors, per labeling. Monitor for corticosteroid toxicity.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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