Drug interactions
Deflazacort + Nilotinib
Severity: Moderate
Deflazacort and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may raise exposure to the active metabolite of deflazacort, increasing corticosteroid adverse effects such as infection, hyperglycemia and adrenal suppression.
What this interaction means in plain words
Deflazacort and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibition of CYP3A4 reduces deflazacort active metabolite clearance.
What to do
Reduce deflazacort dose to about one-third of the usual dose when coadministered with a moderate or strong CYP3A4 inhibitor, per labeling. Monitor for corticosteroid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Nilotinib?
MediHelp rates the interaction as moderate. Deflazacort and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may raise exposure to the active metabolite of deflazacort, increasing corticosteroid adverse effects such as infection, hyperglycemia and adrenal suppression.
How serious is the interaction between Deflazacort and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce deflazacort dose to about one-third of the usual dose when coadministered with a moderate or strong CYP3A4 inhibitor, per labeling. Monitor for corticosteroid toxicity.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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