Drug interactions
Deflazacort + Salbutamol
Severity: Moderate
Deflazacort and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both salbutamol and corticosteroids such as deflazacort can lower serum potassium. Together, especially with high-dose or nebulized salbutamol, hypokalemia may develop and predispose to arrhythmia or muscle weakness.
What this interaction means in plain words
Deflazacort and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Salbutamol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 stimulated intracellular potassium shift and corticosteroid mineralocorticoid-related renal potassium loss.
What to do
Monitor serum potassium when high doses of salbutamol are used with deflazacort, particularly in severe asthma or with other potassium-lowering drugs. Replace potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Salbutamol?
MediHelp rates the interaction as moderate. Deflazacort and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both salbutamol and corticosteroids such as deflazacort can lower serum potassium. Together, especially with high-dose or nebulized salbutamol, hypokalemia may develop and predispose to arrhythmia or muscle weakness.
How serious is the interaction between Deflazacort and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when high doses of salbutamol are used with deflazacort, particularly in severe asthma or with other potassium-lowering drugs. Replace potassium if low.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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