Drug interactions
Deflazacort + Somapacitan
Severity: Moderate
Deflazacort and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucocorticoids at supraphysiologic doses can blunt the growth-promoting effect of growth hormone. In addition, growth hormone inhibits conversion of cortisone to active cortisol, which can unmask adrenal insufficiency in patients on replacement steroids.
What this interaction means in plain words
Deflazacort and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Somapacitan belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism of growth hormone by glucocorticoids, and growth hormone inhibition of 11-beta-HSD1 reducing cortisol activation.
What to do
Monitor growth response and adjust the glucocorticoid to the lowest effective dose. Reassess adrenal replacement needs after somapacitan is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Deflazacort with Somapacitan?
MediHelp rates the interaction as moderate. Deflazacort and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucocorticoids at supraphysiologic doses can blunt the growth-promoting effect of growth hormone. In addition, growth hormone inhibits conversion of cortisone to active cortisol, which can unmask adrenal insufficiency in patients on replacement steroids.
How serious is the interaction between Deflazacort and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth response and adjust the glucocorticoid to the lowest effective dose. Reassess adrenal replacement needs after somapacitan is started.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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