Drug interactions
Deflazacort + Sorafenib
Severity: Minor
Deflazacort and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a corticosteroid prodrug whose active metabolite is a weak CYP3A4 inducer, so it could slightly lower sorafenib exposure. Any clinical effect is likely small and relevant mainly with prolonged use.
What this interaction means in plain words
Deflazacort and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Sorafenib belongs to Oncology.
Why it happens
Possible weak CYP3A4 induction by deflazacort increasing sorafenib metabolism.
What to do
No dose change is normally needed; monitor tumour response during long-term co-treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sorafenib
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Sorafenib?
MediHelp rates the interaction as minor. Deflazacort and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deflazacort is a corticosteroid prodrug whose active metabolite is a weak CYP3A4 inducer, so it could slightly lower sorafenib exposure. Any clinical effect is likely small and relevant mainly with prolonged use.
How serious is the interaction between Deflazacort and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor tumour response during long-term co-treatment.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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